Cepra specializes in the service of carcinogen risk assessment, which includes carcinogenic, mutagenic and reproductive toxic (CMR) substances
Through an integrated consulting and monitoring service, we provide assistance in assessing exposure to CMR substances, reviewing prevention and protection measures, and properly managing documentation and implementing operational procedures.
Our services:
- Identification of carcinogens and/or mutagens
- Verification of the adequacy of the prevention and protection measures taken
- Exposure assessment by means of SAMPLING and CHEMICAL ANALYSIS of airborne agents and verification of compliance with limit values
- Risk assessment with identification of exposed workers and workers for whom there is a health risk
- Preparation of the adaptation/improvement plan
- Preparation and management of the register of exposed workers
Evaluation of exposure to carcinogens, mutagens and reptrotoxic agents should be repeated at least triennially.
With the publication of Legislative Decree No. 135 of September 4, 2024, which implements the fourth amendment of the Carcinogens, Mutagens and Toxic for Reproduction Directive, the scope of the directive has been expanded to include reprotoxic agents.
REPRODUCTION TOXIC AGENTS (so-called reprotoxics), are substances or mixtures that meet the criteria for classification as reprotoxic substances of category 1A or 1B in Annex I of Regulation (EC) No. 1272/2008 (H360).
For example, this category includes agents such as lead compounds, cadmium, phthalates, anesthetic gases, pesticides, some organic solvents (n-methylpyrrolidone, 2-ethoxyethanol, …).
It is therefore necessary to update one’s risk assessment by considering reprotoxic agents in the context of exposure to carcinogens and mutagens.
There are numerous agents classified as carcinogens by the IARC (International Agency for Research on Cancer) and agents classified as CMR cat. 1A or 1B by Regulation (EC) No. 1272/2008.
There are numerous areas of activity in which carcinogenic, mutagenic and reprotoxic substances or mixtures can be found, either as raw materials (e.g., electroplating) or as by-products derived from certain activities (e.g., welding of stainless steels, road asphalting, rubber production).
Below is a table that associates the main CMR agents with the business sectors in which they can be found:
| Carcinogenic/mutagenic agent cat. 1A/1B reg. CLP
Proceedings All. XLII, L.D. 81/08 |
Specific processing | Sectors of activity |
| Crystalline silica powder | Silica or silica sand dosing in particular areas of production | Chemical-formulation of wall paints, cosmetics, plastics, varnishes |
| Use of foundry soils and sands | Foundries | |
| Building demolition, wall shaving | Building work | |
| Processing marble, sandstone, granite, stone, etc. | Bricklayers, funerary arts | |
| Formaldehyde | Galvanic baths | Galvanic |
| Production or processing of urea, phenolic or melamine resins | Various | |
| Core preparation for foundries
Casting |
Foundries | |
| Molding, injection, thermoforming, …, of plastic materials | Plastic compartment | |
| Hardwood dusts | Cutting, sanding hardwood (hardwoods, plywood, MDF, …) | Joinery
Production of furniture, fixtures, packaging Sawmills |
| Gardening work, tree or wood cutting | Gardening companies | |
| Diesel exhaust | Exposure to diesel exhaust | Diesel vehicle repair shops
Use of diesel forklifts or other equipment Use of gardening equipment Gas stations and gas stations Garages |
| Benzene | Gasoline use and dosing | Gas stations and gas stations
Use of gardening equipment |
| Vehicle repair | Gasoline vehicle repair shops | |
| Acrylonitrile, butadiene, VCM vinyl chloride monomer | Plastic resin production o Molding, injection, thermoforming, …, of resins in ABS, PVC | Plastic resin production
Plastic industry |
| Aromatic amines | Production, mixing and installation of epoxy or polyurethane resins (use of MDA or MOCA as crosslinkers) | Plastic resin production
Plastic compartment Production of polyurethane artifacts Production of polyurethane packings or fillings |
| PAHs polycyclic aromatic hydrocarbons | Asphalt paving | Construction-asphalting |
| Use of mineral oils for lubrication | Mechanical machining workshops | |
| Hot laying of bituminous sheathing | Construction companies | |
| Flue cleaning | Chimney sweeps | |
| Rubber vulcanization | Production of rubber products | |
| Hexavalent chromium | Chrome plating, passivation | Galvanic |
| Cement | Construction companies | |
| Fabric dyeing | Textile industry | |
| Leather tanning | Tanning industry | |
| Nickel Compounds | Nickel plating | Galvanic |
| Hexavalent chromium and nickel compounds – welding and laser cutting steel and stainless steel fumes | Welding and/or laser cutting steel and stainless steel | Workshops
Carpentries |
| Cadmium and compounds | Brazing
Soft brazing |
Workshops
Carpentries |
| Cadmium plating | Galvanic | |
| Cobalt and compounds | Galvanic baths | Galvanic |
| Refractory ceramic fibers | Disassembly and recoating of furnace linings | Foundries
Boiler manufacturers |
| Substances or mixtures classified as H350, H350i, H340 | Check the sds of the products used | |