Notification of Hazardous Mixtures

CEPRA offers consultancy services relating to the notification of mixtures to the Hazardous Preparation Archive according to Art. 45 of the CLP.

The services provided are:

- registration of the company to the portal (if necessary)

- support in paying taxes (if they are present)

- transmission of the notification

- number of the poison center to be included in section 1.4 of the SDS


CEPRA provides support and advice for the notification in all the countries of the European Community where the product is on the market.



It is mandatory to notify the following products:

  • Mixtures classified as dangerous for their effects on health and on the basis of their physical and chemical effects;
  • Products authorized or registered as biocides;
  • Detergents;
  • Plant protection products.

The notification, prescribed by Legislative Decree 65/2003 and art. 45 of the CLP Regulation, must be made within thirty days from the date of first placing on the market.



The Istituto Superiore di Sanità is the Italian body responsible for receiving information on preparations placed on the market and considered dangerous for their effects on health or on the basis of their physical and chemical effects, including chemical composition.



In March 2017 the Regulation 2017/542 was published, which aims to harmonize the information to be provided on the subject of emergency health response. (Annex VIII CLP)

This Regulation will apply from 1 January 2020.

The innovations of this Regulation are as follows:

  • A harmonized format for presenting information to designated bodies.
  • The obligation to create a unique formula identifier (UFI).
  • A harmonized system of product categorization.
  • The obligation to notify concentrations ≥ 1% of the mixture components classified as non-hazardous
  • In the case of mixtures placed on the market for purely industrial uses, a simplified notification may be used, provided that a telephone number and an e-mail address are available to allow rapid access to the product information.